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KMID : 0624620140470010021
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BMB Reports
2014 Volume.47 No. 1 p.21 ~ p.26
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Znf45l affects primitive hematopoiesis by regulating transforming growth factor-β signaling
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Chen Huijuan
Sun Huaqin
Tao Dachang
Yang Ping
Bian Shasha
Liu Yunqiang
Zhang Sizhong
Ma Yongxin
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Abstract
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Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display shorter tails and necrosis with reduced expression of hematopoietic maker genes. Furthermore, we revealed that znf45l locates downstream of TGF-β ligands and maintains normal level of TGF-β receptor type II phosphorylation. In brief, our results indicate that znf45l affects initial hematopoietic development through regulation of TGF-β signaling.
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KEYWORD
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Embryo, Hematopoiesis, TGF-β, Zebrafish, Znf45l
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